BICUSPID AORTIC VALVE: GENDER DIFFERENCE IN PREVALENCE, VALVE MORPHOLOGY AND BICUSPID AORTOPATHY
نویسندگان
چکیده
منابع مشابه
Bicuspid Aortic Valve-associated Aortopathy
Patients with bicuspid aortic valve (BAV) have an increased risk of developing ascending aortic aneurysm compared with individuals with a tricuspid aortic valve (TAV). A crucial factor involved in vascular remodeling during aneurysm development is transforming growth factor-β (TGF-β) and impaired signaling of this pathway can alter important extracellular matrix (ECM) protein such us fibronecti...
متن کاملPathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy
Bicuspid aortic valve (BAV) is the most common congenital valvular defect and is associated with ascending aortic dilation (AAD) in a quarter of patients. AAD has been ascribed both to the hemodynamic consequences of normally functioning and abnormal BAV morphology, and to the effect of rare and common genetic variation upon function of the ascending aortic media. AAD manifests in two overall a...
متن کاملBicuspid aortic valve aortopathy: genetics, pathophysiology and medical therapy.
The association between ascending aortic aneurysm (AA) and bicuspid aortic valve (BAV) has been well established. Different genetic, haemodynamic and cardiovascular risk factors have been implicated in the development and progression of AA. However, to date, definite conclusions cannot be drawn regarding the exact molecular, cellular and haemodynamic mechanisms causing BAV-associated aortopathy...
متن کاملInherited aortopathy assessment in bicuspid aortic valve disease relative
Background Bicuspid aortic valve (BAV) is known to be heritable and often shows a concomitant aortopathy which was thought also to be present in some family members. While one recent study reported normal ascending aortic diameters in family members of the general BAV population, little is known about aortic function in such family members. We used advanced aortic cardiovascular magnetic resona...
متن کاملBicuspid aortic valve and associated aortopathy: an update.
Bicuspid aortic valve (BAV) is the most common form of congenital heart disease and most such patients develop cardiovascular complications over time. Recent studies have shed light on one of the most common of these complications, BAV-associated aortopathy. Two distinct BAV phenotypes have been identified, which may have different causes of their associated aortopathy. Increasing evidence sugg...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2016
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(16)32175-1